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Research Projects

We are a research active practice & participate in research studies.  If you are contacted in relation to a study & require further information, please contact the surgery reception team.

2017 Studies:

Study Title: StatinWISE - A series of randomised controlled N-of 1 trials in patients who have discontinued or are considering discontinuing statin use due to muscle-related symptoms to assess if atorvastatin treatment causes more muscle symptoms than placebo.

 

Study Aim and Objectives:  

 

AIM: To determine whether statins cause muscle symptoms.

 

PRIMARY OUTCOME: Patient reported muscle symptoms (pain, weakness, tenderness, stiffness or cramp).  

 

SECONDARY OUTCOME: Relationship between individual trial result and patient decision whether to continue statins long term.

Recruitment in practice: 3 to 5 patients

Duration of Study recruitment: Planned date of last patient enrolment 01/09/2017

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Study Title: STILTS2 - A study examining the common and rare variants associated with thinness - patients aged 18 to 65

Study design: Case-controlled study

 

Study Aim and Objectives:

Genetic factors play a major role in determining the susceptibility to severe Obesity and several genes have been identified in the last 10 years by the team in Cambridge.

At the other end of the weight spectrum, there are people who are persistently thin despite living in an Obesity promoting environment. Thinness (BMI<18kg/m2) is as stable and heritable as severe obesity. However, to date no genetic studies have been conducted in thin people.

 

The aim of this study (STILTS2) is to recruit a substantial cohort of thin people for genetic studies.

 

Recruitment in practice: 1-2 months in practice

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Study Title: Learning about the lives of adults on the autism spectrum and their relatives

Study design: Observational Questionnaire/Survey

Study Aim and Objectives: There is a lack of evidence about effective interventions and no research knowledge regarding the impact of the relationship between ageing and autism. 

This study is the first of its kind in the UK for adults with autism spectrum conditions, as part of a programme of research into ASD across the life course. Experts in ageing and life course, experienced autism researchers, and people on the autism spectrum and relatives will undertake this project. This study will involve engagement with people on the autism spectrum, their parents, siblings and partners, and meeting and discussing with them to understand much more about how living on the spectrum affects people’s daily lives as they age.

Recruitment in practice: Anticipated recruitment of 30 patients - recruitment up to June 2017.

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Study Title: iQuit in Practice - Improving quit rates among smokers in primary care

Study design: 2 parallel group randomised controlled

Study Aim and Objectives: To assess the effectiveness and cost-effectiveness of the iQuit in Practice intervention compared with usual care alone in a definitive pragmatic trial with 6-month follow-up and biochemical verification of abstinence.

Recruitment in practice: 44 smokers - The study will run from 01/04/2016 to 01/03/2019

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Previous studies our patients have taken part in are:

All Heart (Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease) - Primary Objective is to determine whether the addition of allopurinol 600mg daily to usual therapy improves cardiovascular outcomes.

Time Study (Treatment in Morning versus Evening Study) - A study to determine if antihypertensive therapy taken in the evening has improved cardiovascular outcomes compared with more conventional morning dosing.

Momms Study - Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in elderly populations by electronic Decision Support / MoMMs trial (Management of Multiple Medications)

Ecass Study - Evaluation of a Computer Aid for assessing Stomach Symptoms

VBI Study - The objective of this trial is to obtain estimates of the efficacy and cost of a very brief pedometer-based intervention to promote physical activity in adults aged 40-74 years attending an NHS Health Check.

 

 

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